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Br J Pharmacol. 2013 Nov;170(6):1153-66. doi: 10.1111/bph.12399.

Mechanisms governing the health and performance benefits of exercise.

Author information

1
Comparative Biomedical Sciences, The Royal Veterinary College, London, UK.

Abstract

Humans are considered among the greatest if not the greatest endurance land animals. Over the last 50 years, as the population has become more sedentary, rates of cardiovascular disease and its associated risk factors such as obesity, type 2 diabetes and hypertension have all increased. Aerobic fitness is considered protective for all-cause mortality, cardiovascular disease, a variety of cancers, joint disease and depression. Here, I will review the emerging mechanisms that underlie the response to exercise, focusing on the major target organ the skeletal muscle system. Understanding the mechanisms of action of exercise will allow us to develop new therapies that mimic the protective actions of exercise.

KEYWORDS:

endurance; exercise; insulin-like growth factor; myostatin; nuclear receptors; resistance; skeletal muscle

PMID:
24033098
PMCID:
PMC3838691
DOI:
10.1111/bph.12399
[Indexed for MEDLINE]
Free PMC Article

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