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Braz J Microbiol. 2012 Jul;43(3):844-56. doi: 10.1590/S1517-83822012000300001. Epub 2012 Jun 1.

Bioprospecting thermophiles for cellulase production: a review.

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Division of Environmental Sciences, Indian Agricultural Research Institute , New Delhi-110012 , India.


Most of the potential bioprospecting is currently related to the study of the extremophiles and their potential use in industrial processes. Recently microbial cellulases find applications in various industries and constitute a major group of industrial enzymes. Considerable amount of work has been done on microbial cellulases, especially with resurgence of interest in biomass ethanol production employing cellulases and use of cellulases in textile and paper industry. Most efficient method of lignocellulosic biomass hydrolysis is through enzymatic saccharification using cellulases. Significant information has also been gained about the physiology of thermophilic cellulases producers and process development for enzyme production and biomass saccharification. The review discusses the current knowledge on cellulase producing thermophilic microorganisms, their physiological adaptations and control of cellulase gene expression. It discusses the industrial applications of thermophilic cellulases, their cost of production and challenges in cellulase research especially in the area of improving process economics of enzyme production.


Bioethanol; Lignocelluloses; Thermophiles; cellulase

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