Format

Send to

Choose Destination
Obesity (Silver Spring). 2014 Feb;22(2):504-11. doi: 10.1002/oby.20619. Epub 2013 Oct 16.

Insulin secretion and its association with physical activity, fitness and screen time in children.

Author information

1
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada; Division of Endocrinology, Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montreal, Quebec, Canada; Centre de Recherche du CHU Sainte Justine, Montréal, Quebec, Canada.

Abstract

OBJECTIVES:

To determine the independent associations of moderate to vigorous physical activity (MVPA), fitness, screen time, and adiposity with insulin secretion in children.

DESIGN AND METHODS:

Caucasian youth (n = 423/630), 8-10 years old, with at least one obese biological parent, were studied (QUALITY cohort). Insulin secretion was measured using HOMA2-%B, area under the curve (AUC) of insulin to glucose over the first 30 minutes (AUC I/G(t30min)) of the OGTT and AUC I/G(t120min) over 2 hours. Fitness was measured by VO₂peak ; percent fat mass (PFM) by DXA; 7-day MVPA by accelerometry; self-reported screen time included television, video game, or computer use. Models were adjusted for age, sex, season, puberty, PFM, and insulin sensitivity [IS] (HOMA2-IS, Matsuda-ISI).

RESULTS:

PFM was strongly associated with insulin secretion, even after adjustment for IS: for every 1% increase in PFM, insulin secretion increased from 0.3% to 0.8% across indices. MVPA was negatively associated with HOMA2-%B (P < 0.05), but not with OGTT-derived measures. Fitness was negatively associated with AUC I/G(t120min) (P < 0.05). Screen time showed a trend toward higher HOMA2-%B in girls (P = 0.060).

CONCLUSIONS:

In children with an obese parent, lower insulin secretion is associated with lower adiposity, higher MVPA, better fitness, and possibly reduced screen time.

PMID:
24030901
DOI:
10.1002/oby.20619
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center