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Science. 2013 Sep 27;341(6153):1511-4. doi: 10.1126/science.1241628. Epub 2013 Sep 12.

Safeguards for cell cooperation in mouse embryogenesis shown by genome-wide cheater screen.

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  • 1Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Abstract

Ensuring cooperation among formerly autonomous cells has been a central challenge in the evolution of multicellular organisms. One solution is monoclonality, but this option still leaves room for exploitative behavior, as it does not eliminate genetic and epigenetic variability. We therefore hypothesized that embryonic development must be protected by robust regulatory mechanisms that prevent aberrant clones from superseding wild-type cells. Using a genome-wide screen in murine induced pluripotent stem cells, we identified a network of genes (centered on p53, topoisomerase 1, and olfactory receptors) whose down-regulation caused the cells to replace wild-type cells in vitro and in the mouse embryo--without perturbing normal development. These genes thus appear to fulfill an unexpected role in fostering cell cooperation.

PMID:
24030493
DOI:
10.1126/science.1241628
[PubMed - indexed for MEDLINE]
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