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Molecules. 2013 Sep 11;18(9):11144-52. doi: 10.3390/molecules180911144.

An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs.

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1
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.

Abstract

An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.

PMID:
24029747
DOI:
10.3390/molecules180911144
[Indexed for MEDLINE]
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