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Trends Biochem Sci. 2013 Oct;38(10):494-506. doi: 10.1016/j.tibs.2013.07.004. Epub 2013 Sep 10.

Stress granules and cell signaling: more than just a passing phase?

Author information

1
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA.

Abstract

Stress granules (SGs) contain translationally-stalled mRNAs, associated preinitiation factors, and specific RNA-binding proteins. In addition, many signaling proteins are recruited to SGs and/or influence their assembly, which is transient, lasting only until the cells adapt to stress or die. Beyond their role as mRNA triage centers, we posit that SGs constitute RNA-centric signaling hubs analogous to classical multiprotein signaling domains such as transmembrane receptor complexes. As signaling centers, SG formation communicates a 'state of emergency', and their transient existence alters multiple signaling pathways by intercepting and sequestering signaling components. SG assembly and downstream signaling functions may require a cytosolic phase transition facilitated by intrinsically disordered, aggregation-prone protein regions shared by RNA-binding and signaling proteins.

KEYWORDS:

cell signaling; intrinsically disordered; protein aggregation; stress granules; translation

PMID:
24029419
PMCID:
PMC3832949
DOI:
10.1016/j.tibs.2013.07.004
[Indexed for MEDLINE]
Free PMC Article

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