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Epidemiol Infect. 2014 Jul;142(7):1559-65. doi: 10.1017/S0950268813002239. Epub 2013 Sep 13.

Seroprevalence of Sindbis virus and associated risk factors in northern Sweden.

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Department of Clinical Microbiology, Infectious Diseases,Umeå University,Umeå,Sweden.
Department of Public Health and Clinical Medicine, Sunderby Research Unit,Umeå University,Umeå,Sweden.
Department of Virology, Haartman Institute and Department of Veterinary Biosciences,University of Helsinki,Finland.
Department of Clinical Microbiology, Virology,Umeå University,Umeå,Sweden.


Mosquito-borne Sindbis virus (SINV) cause disease characterized by rash, fever and arthritis which often leads to long-lasting arthralgia. To determine the seroprevalence of SINV and associated risk factors in northern Sweden, a randomly selected population aged between 25 and 74 years were invited to join the MONICA study. Serum from 1611 samples were analysed for specific IgG antibodies. Overall, 2·9% had IgG against SINV. More men (3·7%) than women (2·0%) were SINV seropositive (P = 0·047) and it was more common in subjects with a lower educational level (P = 0·013) and living in small, rural communities (P < 0·001). Seropositivity was associated with higher waist circumference (P = 0·1), elevated diastolic blood pressure (P = 0·037), and history of a previous stroke (P = 0·011). In a multiple logistic regression analysis, adjusting for known risk factors for stroke, seropositivity for SINV was an independent predictor of having had a stroke (odds ratio 4·3, 95% confidence interval 1·4-13·0, P = 0·011).

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