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Epidemiol Infect. 2014 Jul;142(7):1559-65. doi: 10.1017/S0950268813002239. Epub 2013 Sep 13.

Seroprevalence of Sindbis virus and associated risk factors in northern Sweden.

Author information

1
Department of Clinical Microbiology, Infectious Diseases,Umeå University,Umeå,Sweden.
2
Department of Public Health and Clinical Medicine, Sunderby Research Unit,Umeå University,Umeå,Sweden.
3
Department of Virology, Haartman Institute and Department of Veterinary Biosciences,University of Helsinki,Finland.
4
Department of Clinical Microbiology, Virology,Umeå University,Umeå,Sweden.

Abstract

Mosquito-borne Sindbis virus (SINV) cause disease characterized by rash, fever and arthritis which often leads to long-lasting arthralgia. To determine the seroprevalence of SINV and associated risk factors in northern Sweden, a randomly selected population aged between 25 and 74 years were invited to join the MONICA study. Serum from 1611 samples were analysed for specific IgG antibodies. Overall, 2·9% had IgG against SINV. More men (3·7%) than women (2·0%) were SINV seropositive (P = 0·047) and it was more common in subjects with a lower educational level (P = 0·013) and living in small, rural communities (P < 0·001). Seropositivity was associated with higher waist circumference (P = 0·1), elevated diastolic blood pressure (P = 0·037), and history of a previous stroke (P = 0·011). In a multiple logistic regression analysis, adjusting for known risk factors for stroke, seropositivity for SINV was an independent predictor of having had a stroke (odds ratio 4·3, 95% confidence interval 1·4-13·0, P = 0·011).

PMID:
24029159
DOI:
10.1017/S0950268813002239
[Indexed for MEDLINE]
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