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J Int Med Res. 2013 Oct;41(5):1768-72. doi: 10.1177/0300060513490609. Epub 2013 Sep 12.

Osteoporotic fractures and persistent non-fusion of the hand epiphyses caused by empty sella syndrome in an adult: a case report.

Author information

1
Department of Orthopaedics, Changzheng Hospital, The Second Military Medical University, Shanghai, China.

Abstract

We report a case of primary empty sella syndrome (ESS) resulting in osteoporotic fractures and persistent non-fusion of the hand epiphyses, and discuss the potential pathogenesis of this disease. A 41-year-old man presented with pain in the right hand and back after a fall. X-radiographs revealed persistent epiphyses and severe osteoporosis. Serum phosphorus and prolactin levels were above normal levels, and free triiodothyronine, free thyroxine and testosterone levels were below normal limits. Magnetic resonance imaging of the head revealed empty sella. A lumbar bone mineral density examination indicated severe osteoporosis. ESS caused a systemic hormone disorder in this patient, resulting in osteoporotic fractures and persistent non-fusion of the hand epiphyses. Possible causes of this anomaly are chronic or congenital abnormities of the pituitary gland.

KEYWORDS:

Osteoporosis; empty sella syndrome; hyperprolactinaemia; hypogonadism; pituitary

PMID:
24029021
DOI:
10.1177/0300060513490609
[Indexed for MEDLINE]

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