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ScientificWorldJournal. 2013 Aug 21;2013:186505. doi: 10.1155/2013/186505. eCollection 2013.

Antimelanoma and antityrosinase from Alpinia galangal constituents.

Author information

1
Department of Food Science, National Chiayi University, Chiayi 60083, Taiwan.

Abstract

Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the proliferation of melanoma cells in the cell viability assay. This research was also taken on the tests to B16-F10 cell line and showed minor inhibitory consequences of cellular tyrosinase activities and melanin contents. Our results revealed the anticancer effects of A. galangal compounds, and therefore, the target compounds could be potentially applied in the therapeutic application and the food industry.

PMID:
24027439
PMCID:
PMC3763262
DOI:
10.1155/2013/186505
[Indexed for MEDLINE]
Free PMC Article

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