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J Virol. 2013 Dec;87(23):13029-34. doi: 10.1128/JVI.02112-13. Epub 2013 Sep 11.

A microRNA encoded by Autographa californica nucleopolyhedrovirus regulates expression of viral gene ODV-E25.

Author information

1
School of Life Science, Sun Yat-sen University, Guangzhou, People's Republic of China.

Abstract

Baculovirus-encoded microRNAs (miRNAs) have been described in Bombyx mori nucleopolyhedrovirus; however, most of their functions remain unclear. Here we report the identification and characterization of an miRNA encoded by Autographa californica nucleopolyhedrovirus. The identified miRNA, AcMNPV-miR-1, perfectly matched a segment in the coding sequence of the viral gene ODV-E25 and downregulated ODV-E25 mRNA expression, which likely resulted in a reduction of infectious budded virions and accelerated the formation of occlusion-derived virions.

PMID:
24027316
PMCID:
PMC3838118
DOI:
10.1128/JVI.02112-13
[Indexed for MEDLINE]
Free PMC Article

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