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J Neurosci. 2013 Sep 11;33(37):14681-92. doi: 10.1523/JNEUROSCI.5231-12.2013.

Lhx3-Chx10 reticulospinal neurons in locomotor circuits.

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  • 1Centre de Recherche du CHU de Québec, CHUL-Neurosciences, Québec City, Québec G1V 4G2, Canada, Département de Psychiatrie et Neurosciences, Université Laval, Québec City, Québec G1K 7P4, Canada, Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada, and Department of Surgery (Neurosurgery), Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.

Abstract

Motor behaviors result from the interplay between the brain and the spinal cord. Reticulospinal neurons, situated between the supraspinal structures that initiate motor movements and the spinal cord that executes them, play key integrative roles in these behaviors. However, the molecular identities of mammalian reticular formation neurons that mediate motor behaviors have not yet been determined, thus limiting their study in health and disease. In the medullary reticular formation of the mouse, we identified neurons that express the transcription factors Lhx3 and/or Chx10, and demonstrate that these neurons form a significant component of glutamatergic reticulospinal pathways. Lhx3-positive medullary reticular formation neurons express Fos following a locomotor task in the adult, indicating that they are active during walking. Furthermore, they receive functional inputs from the mesencephalic locomotor region and have electrophysiological properties to support tonic repetitive firing, both of which are necessary for neurons that mediate the descending command for locomotion. Together, these results suggest that Lhx3/Chx10 medullary reticular formation neurons are involved in locomotion.

PMID:
24027269
DOI:
10.1523/JNEUROSCI.5231-12.2013
[PubMed - indexed for MEDLINE]
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