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Neuroreport. 2013 Nov 13;24(16):889-93. doi: 10.1097/WNR.0000000000000014.

Semantic processing and response inhibition.

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aCenter for BrainHealth bCallier Center for Communication Disorders, University of Texas at Dallas, Texas cDepartment of Speech and Hearing Science, University of Illinois at Urbana-Champaign, Urbana, Illinois dMedical Scientist Training Program, Washington University in St Louis, Missouri eDepartment of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.


The present study examined functional MRI (fMRI) BOLD signal changes in response to object categorization during response selection and inhibition. Young adults (N=16) completed a Go/NoGo task with varying object categorization requirements while fMRI data were recorded. Response inhibition elicited increased signal change in various brain regions, including medial frontal areas, compared with response selection. BOLD signal in an area within the right angular gyrus was increased when higher-order categorization was mandated. In addition, signal change during response inhibition varied with categorization requirements in the left inferior temporal gyrus (lIT). lIT-mediated response inhibition when inhibiting the response only required lower-order categorization, but lIT mediated both response selection and inhibition when selecting and inhibiting the response required higher-order categorization. The findings characterized mechanisms mediating response inhibition associated with semantic object categorization in the 'what' visual object memory system.

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