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Redox Biol. 2013 May 23;1:313-8. doi: 10.1016/j.redox.2013.05.001.

A tale of two gases: NO and H2S, foes or friends for life?

Author information

1
Department of Pathology, LSU Health-Shreveport, USA.

Abstract

Nitric oxide (NO) and hydrogen sulfide (H2S) have emerged as dominant redox regulators of numerous aspects of cellular and physiological functions within several organ systems included cardiovascular, immune and neurological tissues. Recent studies have begun to reveal that these two gaseous molecules may have redundant or overlapping pathophysiological functions often involving similar molecular targets. However, it remains less clear when and how NO and H2S may interact under biological and disease processes. In this graphical review, we discuss the current understanding of NO and H2S interactions and how they may functionally influence each other and what this may mean for biology and mechanisms of disease.

KEYWORDS:

Cardiovascular disease; Chemistry; Redox biology; Thiol; Vascular biology

PMID:
24024166
PMCID:
PMC3757701
DOI:
10.1016/j.redox.2013.05.001
[Indexed for MEDLINE]
Free PMC Article

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