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PLoS One. 2013 Sep 4;8(9):e73233. doi: 10.1371/journal.pone.0073233. eCollection 2013.

A reduce and replace strategy for suppressing vector-borne diseases: insights from a deterministic model.

Author information

1
Department of Mathematics and Biomathematics Graduate Program, North Carolina State University, Raleigh, North Carolina, United States of America.

Abstract

Genetic approaches for controlling disease vectors have aimed either to reduce wild-type populations or to replace wild-type populations with insects that cannot transmit pathogens. Here, we propose a Reduce and Replace (R&R) strategy in which released insects have both female-killing and anti-pathogen genes. We develop a mathematical model to numerically explore release strategies involving an R&R strain of the dengue vector Aedes aegypti. We show that repeated R&R releases may lead to a temporary decrease in mosquito population density and, in the absence of fitness costs associated with the anti-pathogen gene, a long-term decrease in competent vector population density. We find that R&R releases more rapidly reduce the transient and long-term competent vector densities than female-killing releases alone. We show that releases including R&R females lead to greater reduction in competent vector density than male-only releases. The magnitude of reduction in total and competent vectors depends upon the release ratio, release duration, and whether females are included in releases. Even when the anti-pathogen allele has a fitness cost, R&R releases lead to greater reduction in competent vectors than female-killing releases during the release period; however, continued releases are needed to maintain low density of competent vectors long-term. We discuss the results of the model as motivation for more detailed studies of R&R strategies.

PMID:
24023839
PMCID:
PMC3762895
DOI:
10.1371/journal.pone.0073233
[Indexed for MEDLINE]
Free PMC Article
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