Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS One. 2013 Sep 4;8(9):e72539. doi: 10.1371/journal.pone.0072539. eCollection 2013.

The effects of caffeine on sleep and maturational markers in the rat.

Author information

1
Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland ; Neuroscience Center Zurich (ZNZ), University and ETH Zurich, Zurich, Switzerland.

Abstract

Adolescence is a critical period for brain maturation during which a massive reorganization of cortical connectivity takes place. In humans, slow wave activity (<4.5 Hz) during NREM sleep was proposed to reflect cortical maturation which relies on use-dependent processes. A stimulant like caffeine, whose consumption has recently increased especially in adolescents, is known to affect sleep wake regulation. The goal of this study was to establish a rat model allowing to assess the relationship between cortical maturation and sleep and to further investigate how these parameters are affected by caffeine consumption. To do so, we assessed sleep and markers of maturation by electrophysiological recordings, behavioral and structural readouts in the juvenile rat. Our results show that sleep slow wave activity follows a similar inverted U-shape trajectory as already known in humans. Caffeine treatment exerted short-term stimulating effects and altered the trajectory of slow wave activity. Moreover, caffeine affected behavioral and structural markers of maturation. Thus, caffeine consumption during a critical developmental period shows long lasting effects on sleep and brain maturation.

PMID:
24023748
PMCID:
PMC3762801
DOI:
10.1371/journal.pone.0072539
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center