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Anticancer Res. 2013 Sep;33(9):4007-11.

E6/E7 mRNA expression of high-risk HPV types in 849 Greek women.

Author information

1
Department of Virology, St. Savvas, Regional Anticancer Oncology Hospital of Athens, 171 Alexandras Avenue, 11522 Athens, Greece. +30 2106409461, epanot@tee.gr.

Abstract

AIM:

The goal of this study was to investigate human papillomavirus (HPV) geno typing and high-risk HPV E6/E7 mRNA expression in 849 women.

PATIENTS AND METHODS:

849 Cervical samples were obtained from patients attending an outpatient clinic to have their annual gynaecological check-up. All patients underwent a conventional Pap test. The patients were also offered HPV test with the knowledge that it is not part of the screening.

RESULTS:

Overall prevalence of HPV DNA was 41.3%, while E6/E7 mRNA expression was found in 20.7% of the patients. HPV DNA and E6/E7 mRNA expression were detected in 21.1% and 9.1% of normal cytological samples, respectively, 38.1% and 23.8% of atypical squamous cells of unknown significance, 84.8% and 40.7% of low-grade squamous intraepithelial lesions, and 96.4% and 89.3% of high-grade squamous intraepithelial lesions, respectively. HPV 16 was the most frequent genotype identified.

CONCLUSION:

E6/E7mRNA detection might be useful as a screening marker for the early prediction of active infections and subsequent progression to severe dysplasia.

KEYWORDS:

E6; E7; Greece; HPV

PMID:
24023342
[Indexed for MEDLINE]

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