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Anticancer Res. 2013 Sep;33(9):3867-9.

Morbid obesity does not disadvantage patients with in situ or early-stage carcinoma undergoing breast-conserving surgery.

Author information

1
Division of Therapeutic Radiology, Louisiana State University Health, 1501 Kings Highway, Shreveport, LA 71130, U.S.A. fampil@lsuhsc.edu.

Abstract

AIM:

To determine whether morbidly obese (MO) patients with early-stage breast cancer (BCa) benefit from standard-of-care interventions.

PATIENTS AND METHODS:

Between 1992 and 2005, 100 patients underwent breast-conserving surgery and postoperative whole-breast irradiation of 50 Gy for minimally invasive BCa with tumor-free surgical margins. Twenty-seven MO women were compared to 73 non-morbidly obese (NMO) patients.

RESULTS:

At 10 years, the cumulative disease-free survival rate for the NMO patients was 91% compared to the non-statistically significant lower rate of 89% in the MO women (p=0.66). Patients who were excessively obese were not at an increased risk for local (p=0.99) or regional disease recurrence (p=0.29).

CONCLUSION:

The results suggest that patients with minimally invasive BCa and excessively large body habitus should not be disqualified from receiving breast-conserving therapy.

KEYWORDS:

Morbid obesity; breast cancer; breast-conservation surgery; chemotherapy; radiotherapy

PMID:
24023321
[Indexed for MEDLINE]
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