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Clin Exp Rheumatol. 2013 Nov-Dec;31(6 Suppl 79):S60-3. Epub 2013 Sep 10.

Increased levels of IL-17A in patients with fibromyalgia.

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1
Department of Morphology, Institute of Biological Science, Federal University of Minas Gerais, Brazil. pernambucoap@ymail.com.

Abstract

OBJECTIVES:

The aim of this study was to evaluate the plasma levels of IL-17A in fibromyalgia patients, and to look for any correlations between this data and the concentrations of some pro- and anti-inflammatory cytokines.

METHODS:

We performed a study including 58 fibromyalgia patients and 39 healthy women matched for age and body mass index. The plasma levels of IL-17A and other pro- and anti-inflammatory cytokines were measured by using the technique of cytometric bead array (CBA). The analysis of differences between groups was performed using Mann-Whitney test and the analysis of the correlations by Spearman's correlation test.

RESULTS:

The analyses showed that fibromyalgia patients present increased levels of IL-17A. They also revealed that plasma concentrations of IL17A positively correlate with levels of IL-2, IL-4 and IL-10, TNF and IFNγ.

CONCLUSIONS:

As far as we are aware, this is the first study to demonstrate increased levels of IL17A in fibromyalgia patients. The positive correlation between the levels of IL-17A and of other cytokines strengthens the hypothesis of the involvement of inflammatory mechanisms in the development of this syndrome.

PMID:
24021410
[Indexed for MEDLINE]
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