Abstract
Detection of immunoglobulins in epidermal cell nuclei or in vivo antinuclear antibodies on direct immunoflorescence microscopy of skin biopsies is an easily detectable immunopathologic feature. It is an unusual, but not totally rare, occurrence in systemic connective tissue disorders. This positive epidermal nuclear reaction is found to be commonly associated with immunoglobulin G.
MeSH terms
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Antibodies, Antinuclear / analysis*
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Antibodies, Antinuclear / blood
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Antibody Specificity
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Biopsy
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Cell Nucleus / immunology
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Connective Tissue Diseases / immunology*
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Connective Tissue Diseases / pathology
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Epidermis / immunology*
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Fluorescent Antibody Technique, Direct*
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Humans
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Immunoglobulin G / analysis
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Immunoglobulin G / blood
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Retrospective Studies
Substances
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Antibodies, Antinuclear
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Immunoglobulin G