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Vaccine. 2014 Feb 26;32(10):1192-8. doi: 10.1016/j.vaccine.2013.08.076. Epub 2013 Sep 7.

Seroprevalence of rubella in the cord blood of pregnant women and congenital rubella incidence in Nha Trang, Vietnam.

Author information

1
Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Electronic address: masami5008@gmail.com.
2
Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan.
3
Modelling & Economics Unit, Public Health England, Colindale Ave, London, Greater London, UK; Department of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, Keppel Street, London, England, United Kingdom.
4
Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
5
Khanh Hoa Provincial Public Health Service, Nha Trang, Viet Nam.
6
National Institute of Hygiene and Epidemiology, Yecxanh, Hai Ba Trung, Ha Noi, Viet Nam.
7
Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Electronic address: hiromori@nagasaki-u.ac.jp.

Abstract

To investigate susceptibility to and factors associated with rubella infection among pregnant mothers and to estimate the burden of congenital rubella infection (CRI) in Vietnam where rubella-containing vaccine (RCV) is not included in the routine immunization program, we conducted a prospective cohort study in Nha Trang, Vietnam between 2009 and 2010. Rubella-specific immunoglobulin-M and immunoglobulin-G were investigated in cord blood samples by enzyme immunoassay. Corresponding clinical-epidemiological data were analyzed and the national congenital rubella syndrome (CRS) incidence was estimated using modeling. We enrolled 1988 pairs of mothers aged 17-45 years and their newborn babies. No mothers had received RCV. Multivariate analysis revealed that mothers aged 17-24 (aOR 2.5, 95% CI: 1.7-3.8) or 25-34 (1.4, 1.0-2.1) years were more likely to be susceptible than those aged 35-45 years. Overall 28.9% (574/1988, 95% CI: 26.9-30.9%) of mothers were seronegative. The CRI rate was 151 (95% CI: 0-322) per 100,000 live births. Modeling estimated that 3788 babies (95% CI: 3283-4143) were born with CRS annually in Vietnam with an overall CRS incidence of 234 (95% CI: 207-262) cases per 100,000 live births. A substantial proportion of women of childbearing age (WCBA) are at risk of rubella infection during pregnancy and this can result in a high frequency of miscarriage or burden of CRS across Vietnam. Prompt introduction of RCV into national immunization program with catch-up vaccination to children and WCBA will reduce CRI in Vietnam.

KEYWORDS:

Congenital rubella syndrome; Cord blood; IgG; IgM; Incidence; Modeling; Seroprevalence; Women of childbearing age

PMID:
24021315
DOI:
10.1016/j.vaccine.2013.08.076
[Indexed for MEDLINE]

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