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Future Microbiol. 2013 Sep;8(9):1107-16. doi: 10.2217/fmb.13.84.

Elucidating the immunological function of the Cryptococcus neoformans capsule.

Author information

1
Department of Experimental Medicine, Microbiology Section, University of Perugia, Perugia, 06132, Italy.

Abstract

The encapsulated fungal pathogen Cryptococcus neoformans represents a significant agent of life-threatening infections in immunocompromised subjects. A unique characteristic of Cryptococcus species is the presence of a polysaccharide capsule, which is essential for virulence and endows Cryptococcus with potent immunoregulatory properties. This review provides an overview of the immunological properties of the principal components of C. neoformans capsule.

PMID:
24020739
DOI:
10.2217/fmb.13.84
[Indexed for MEDLINE]
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