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Int J Epidemiol. 2014 Oct;43(5):1417-24. doi: 10.1093/ije/dyt128. Epub 2013 Sep 9.

Cohort profile: Andhra Pradesh Children and Parents Study (APCAPS).

Author information

1
Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK, National Institute of Nutrition, Indian Council for Medical Research, Hyderabad, India, Public Health Foundation of India, New Delhi, India, School of Social and Community Medicine, University of Bristol, Bristol, UK, Department of Anthropology, University of Delhi, Delhi, India, South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia and Centre for Chronic Disease Control, New Delhi, India Sanjay.Kinra@lshtm.ac.uk.
2
Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK, National Institute of Nutrition, Indian Council for Medical Research, Hyderabad, India, Public Health Foundation of India, New Delhi, India, School of Social and Community Medicine, University of Bristol, Bristol, UK, Department of Anthropology, University of Delhi, Delhi, India, South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia and Centre for Chronic Disease Control, New Delhi, India.
3
Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK, National Institute of Nutrition, Indian Council for Medical Research, Hyderabad, India, Public Health Foundation of India, New Delhi, India, School of Social and Community Medicine, University of Bristol, Bristol, UK, Department of Anthropology, University of Delhi, Delhi, India, South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia and Centre for Chronic Disease Control, New Delhi, India Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK, National Institute of Nutrition, Indian Council for Medical Research, Hyderabad, India, Public Health Foundation of India, New Delhi, India, School of Social and Community Medicine, University of Bristol, Bristol, UK, Department of Anthropology, University of Delhi, Delhi, India, South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia and Centre for Chronic Disease Control, New Delhi, India.

Abstract

The Andhra Pradesh Children and Parents Study (APCAPS) was originally established to study the long-term effects of early-life undernutrition on risk of cardiovascular disease. Its aims were subsequently expanded to include trans-generational influences of other environmental and genetic factors on chronic diseases in rural India. It builds on the Hyderabad Nutrition Trial (HNT) conducted in 1987-90 to compare the effects on birthweight of a protein-calorie supplement for pregnant women and children. The index children of HNT and their mothers were retraced and examined in 2003-05, and the children re-examined as young adults aged 18-21 years in 2009-10. The cohort was expanded to include both parents and siblings of the index children in a recently completed follow-up conducted in 2010-12 (N=∼6225 out of 10,213 participants). Recruitment of the remaining residents of these 29 villages (N=∼55,000) in Ranga Reddy district of Andhra Pradesh is now under way. Extensive data on socio-demographic, lifestyle, medical, anthropometric, physiological, vascular and body composition measures, DNA, stored plasma, and assays of lipids and inflammatory markers on APCAPS participants are available. Details of how to access these data are available from the corresponding author.

PMID:
24019421
PMCID:
PMC4190511
DOI:
10.1093/ije/dyt128
[Indexed for MEDLINE]
Free PMC Article

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