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Nat Rev Microbiol. 2013 Oct;11(10):688-700. doi: 10.1038/nrmicro3098. Epub 2013 Sep 10.

The ins and outs of hepatitis C virus entry and assembly.

Author information

1
Department of Microbial Pathogenesis, Yale University, New Haven, Connecticut 06536, USA.

Abstract

Hepatitis C virus, a major human pathogen, produces infectious virus particles with several unique features, such as an ability to interact with serum lipoproteins, a dizzyingly complicated process of virus entry, and a pathway of virus assembly and release that is closely linked to lipoprotein secretion. Here, we review these unique features, with an emphasis on recent discoveries concerning virus particle structure, virus entry and virus particle assembly and release.

PMID:
24018384
PMCID:
PMC3897199
DOI:
10.1038/nrmicro3098
[Indexed for MEDLINE]
Free PMC Article

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