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Am Heart J. 2013 Sep;166(3):392-400. doi: 10.1016/j.ahj.2013.05.021. Epub 2013 Jul 3.

Exercise-mediated changes in high-density lipoprotein: impact on form and function.

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Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH.


The goal of this systematic review was to assess the current understanding of the effects of exercise intervention on high-density lipoprotein (HDL) cholesterol (HDL-C) and changes in HDL function as well as modification of these effects by genomic factors. The reviewed studies demonstrate that exercise has modest effects on HDL-C with limited data suggesting an effect on HDL function. Genetic polymorphisms in proteins associated with HDL metabolism play a role in modifying the HDL-C response to exercise and possibly its function. Exercise as an intervention for patients at risk for cardiovascular events can lead to small improvements in HDL-C and potential changes in HDL function. There is an important modifier effect of genetics in determining these changes.

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