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Am Heart J. 2013 Sep;166(3):392-400. doi: 10.1016/j.ahj.2013.05.021. Epub 2013 Jul 3.

Exercise-mediated changes in high-density lipoprotein: impact on form and function.

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1
Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH.

Abstract

The goal of this systematic review was to assess the current understanding of the effects of exercise intervention on high-density lipoprotein (HDL) cholesterol (HDL-C) and changes in HDL function as well as modification of these effects by genomic factors. The reviewed studies demonstrate that exercise has modest effects on HDL-C with limited data suggesting an effect on HDL function. Genetic polymorphisms in proteins associated with HDL metabolism play a role in modifying the HDL-C response to exercise and possibly its function. Exercise as an intervention for patients at risk for cardiovascular events can lead to small improvements in HDL-C and potential changes in HDL function. There is an important modifier effect of genetics in determining these changes.

PMID:
24016485
DOI:
10.1016/j.ahj.2013.05.021
[Indexed for MEDLINE]
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