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Indian J Pharmacol. 2013 Jul-Aug;45(4):330-3. doi: 10.4103/0253-7613.114997.

Pharmacokinetics of single-dose primaquine in patients with chronic kidney dysfunction.

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  • 1Department of Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India.

Abstract

AIM:

The pharmacokinetics of primaquine has not been studied in special populations. Being a basic compound, preferential binding to alpha-1 acid glycoprotein and substrate for P-glycoprotein, may predispose the drug for an altered pharmacokinetics in states of renal dysfunction. This study attempts to evaluate the pharmacokinetics of a single oral dose (15 mg) of primaquine in severely impaired renal function and end stage renal dysfunction patients compared to healthy participants.

MATERIALS AND METHODS:

Twelve patients each with chronic kidney disease classified as either Stage IV or V (not on dialysis) were recruited. Data from 12 healthy participants was used as concurrent controls. Serial blood collections were performed following a single dose 15 mg Primaquine orally. Primaquine concentrations were measured in the plasma using a validated HPLC method.

RESULTS:

The Cmax [median (range) in ng/ml] was 29.3 (14.6-104.3), 40.3 (14.8 - 78.6), and 49.8 (15 - 169.6) and the tmax [median (range) in hours] was 3.0 (1.0- 6.0), 2.0 (1.5 - 8) and 2.0 (1.0 - 4.0) for healthy and stage IV, V (not on dialysis) CKD participants, respectively. No statistically significant difference was observed in any of the pharmacokinetic parameters between healthy, stage IV and V CKD participants.

CONCLUSION:

Pharmacokinetics of single oral dose primaquine (15 mg) does not appear to be altered in patients with severely impaired renal function and end stage renal dysfunction. A change in dose or frequency of the drug administration perhaps may not be required in this population.

KEYWORDS:

Antimalarials; chronic kidney disease; renal failure; special populations

PMID:
24014905
PMCID:
PMC3757598
DOI:
10.4103/0253-7613.114997
[PubMed - indexed for MEDLINE]
Free PMC Article
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