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J Mol Cell Biol. 2013 Oct;5(5):354-5. doi: 10.1093/jmcb/mjt034. Epub 2013 Sep 6.

Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach.

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1
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small molecules alone (i.e. without Yamanaka factors) can successfully establish iPSCs from mouse somatic cells.

PMID:
24014886
DOI:
10.1093/jmcb/mjt034
[Indexed for MEDLINE]
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