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Bioresour Technol. 2013 Nov;147:442-8. doi: 10.1016/j.biortech.2013.08.045. Epub 2013 Aug 14.

In-situ combination of fermentation and electrodialysis with bipolar membranes for the production of lactic acid: continuous operation.

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CAS, Key Laboratory of Soft Matter Chemistry, Laboratory of Functional Membranes, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.


An experimental study was carried out to achieve a continuous integrated operation of fermentation and electrodialysis with bipolar membranes (EDBM). There need three steps to accomplish this experiment: (1) individual continuous fermentation; (2) individual continuous EDBM; (3) integrated operation of fermentation and EDBM under continuous condition. The results indicate that the maximum feed rate (fermenter can afford) is 0.24 L/h, which is also equal to the feed rate of the subsequent individual continuous EDBM. During continuous EDBM, the recovery ratio of lactate from the fermentation broth can reach 69.5% under a current density of 40 mA/cm(2). The net end concentration and total molar quantity for lactic acid can reach 1.46 mol/L and 2.18 mol, and for OH(-) are 1.32 mol/L and 1.70 mol, respectively. The integration can be achieved only under an initial alkali concentration of no less than 1 mol/L and a current density of no less than 30 mA/cm(2).


Bipolar membranes; Electrodialysis; Fermentation; Ion exchange membrane; Lactic acid

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