Format

Send to

Choose Destination
Biochem Biophys Res Commun. 2013 Oct 4;439(4):464-70. doi: 10.1016/j.bbrc.2013.08.091. Epub 2013 Sep 6.

Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking.

Author information

1
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA.

Abstract

Recent studies demonstrated that the antihypertensive drug Valsartan improved spatial and episodic memory in mouse models of Alzheimer's Disease (AD) and human subjects with hypertension. However, the molecular mechanism by which Valsartan can regulate cognitive function is still unknown. Here, we investigated the effect of Valsartan on dendritic spine formation in primary hippocampal neurons, which is correlated with learning and memory. Interestingly, we found that Valsartan promotes spinogenesis in developing and mature neurons. In addition, we found that Valsartan increases the puncta number of PSD-95 and trends toward an increase in the puncta number of synaptophysin. Moreover, Valsartan increased the cell surface levels of AMPA receptors and selectively altered the levels of spinogenesis-related proteins, including CaMKIIα and phospho-CDK5. These data suggest that Valsartan may promote spinogenesis by enhancing AMPA receptor trafficking and synaptic plasticity signaling.

KEYWORDS:

AMPA receptor; CaMKIIα; Spinogenesis; Valsartan

PMID:
24012668
PMCID:
PMC3840727
DOI:
10.1016/j.bbrc.2013.08.091
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center