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Cytokine. 2013 Nov;64(2):477-85. doi: 10.1016/j.cyto.2013.07.022. Epub 2013 Sep 3.

IL-17 family: cytokines, receptors and signaling.

Author information

1
Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Abstract

The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. Although IL-17A is the signature cytokine produced by T helper 17 (Th17) cells, IL-17A and other IL-17 family cytokines have multiple sources ranging from immune cells to non-immune cells. The IL-17 family signals via their correspondent receptors and activates downstream pathways that include NFκB, MAPKs and C/EBPs to induce the expression of anti-microbial peptides, cytokines and chemokines. The proximal adaptor Act1 is a common mediator during the signaling of all IL-17 cytokines so far and is thus involved in IL-17 mediated host defense and IL-17-driven autoimmune conditions. This review will give an overview and recent updates on the IL-17 family, the activation and regulation of IL-17 signaling as well as diseases associated with this cytokine family.

KEYWORDS:

Act1; IL-17R; Interleukin 17; Signaling transduction

PMID:
24011563
PMCID:
PMC3867811
DOI:
10.1016/j.cyto.2013.07.022
[Indexed for MEDLINE]
Free PMC Article

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