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Trends Endocrinol Metab. 2014 Jan;25(1):15-22. doi: 10.1016/j.tem.2013.08.002. Epub 2013 Sep 3.

Unlocking the biology of RAGE in diabetic microvascular complications.

Author information

1
Diabetes Research Program, Division of Endocrinology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
2
Diabetes Research Program, Division of Endocrinology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address: annmarie.schmidt@nyumc.org.

Abstract

The discovery of the receptor for advanced glycation end-products (RAGE) set the stage for the elucidation of important mechanisms underpinning diabetic complications. RAGE transduces the signals of advanced glycation end-products (AGEs), proinflammatory S100/calgranulins, and high mobility group box 1 (HMGB1), and is a one of a family of receptors for lysophosphatidic acid (LPA). These ligand tales weave a theme of vascular perturbation and inflammation linked to the pathogenesis of the chronic complications of diabetes. Once deemed implausible, this concept of inflammatory cues participating in diabetic complications is now supported by a plethora of experimental evidence in the macro- and microvasculature. We review the biology of ligand-RAGE signal transduction and its roles in diabetic microvascular complications, from animal models to human subjects.

KEYWORDS:

complications; diabetes; inflammation; ligands; receptor for AGE

PMID:
24011512
PMCID:
PMC3877224
DOI:
10.1016/j.tem.2013.08.002
[Indexed for MEDLINE]
Free PMC Article

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