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Ugeskr Laeger. 2013 Sep 9;175(37):2090-3.

[Ketamine for treatment of acute depression].

[Article in Danish]

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1
Center for Psykiatrisk Forskning, Aarhus Universitetshospital, Risskov, Skovagervej 2, 8240 Risskov. simon@dadlnet.dk.

Abstract

In clinical trials a single dose of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has shown a rapid antidepressant effect in patients with treatment-resistant depression and bipolar depression. The implications of glutaminergic mechanisms in depression and the rapid effect of a single dose of ketamine could open new pathways to understand the pathophysiology of depression and the development of novel rapid-acting antidepressant drugs.

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PMID:
24011203
[Indexed for MEDLINE]
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