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Org Lett. 2013 Sep 20;15(18):4802-5. doi: 10.1021/ol402193b. Epub 2013 Sep 6.

Synthesis of glaucogenin D, a structurally unique disecopregnane steroid with potential antiviral activity.

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1
Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry , Chinese Academy of Sciences, 345 Lingling Road, Shanghai, China.

Abstract

The first chemical synthesis of glaucogenin D, a 13,14:14,15-disecopregnane steroid with potential antiviral activity, has been accomplished in 12 steps from a hirundigenin-type intermediate. The present route would also be amenable to the synthesis of natural and unnatural glaucogenin derivatives for SAR studies.

PMID:
24011079
DOI:
10.1021/ol402193b
[Indexed for MEDLINE]
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