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Structure. 2013 Sep 3;21(9):1479-81. doi: 10.1016/j.str.2013.08.011.

A new RING tossed into an old HAT.

Author information

1
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

p300 and CBP are multi-domain histone acetyltransferases (HATs) that regulate gene expression and are mutated in human diseases including cancer. Delvecchio and colleagues report the structure of the p300 catalytic core, revealing the presence of a previously unknown RING domain that regulates the enzyme's activity.

PMID:
24010705
PMCID:
PMC3836368
DOI:
10.1016/j.str.2013.08.011
[Indexed for MEDLINE]
Free PMC Article

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