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Zhong Yao Cai. 2013 Mar;36(3):468-71.

[Study on preparation and optimization of saikoside liposomes].

[Article in Chinese]

Author information

1
School of Pharmacy, Henan University of TCM, Zhengzhou 450046 China. guanyanbin96@126.com

Abstract

OBJECTIVE:

To optimize the prescription and technique for preparing saikoside (SS) liposomes and evaluate its quality.

METHODS:

The preparation methods of liposomes included film dispersion, ether injection, reverse phase evaporation and pH gradients were explored. The encapsulation ratio was determined by macroreticular resin method. The main factors affecting encapsulation ratio were studied by single factor analysis and central composite design.

RESULTS:

The appearance of SS liposomes prepared by optimized method was satisfactory. The encapsulation ratio was more than 60% and the verage particle size of SS liposomes was 110 nm.

CONCLUSION:

The formulation and preparation process is practical and simple for the preparation of SS liposomes. It is valuable to be further studied.

PMID:
24010331
[Indexed for MEDLINE]
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