Send to

Choose Destination
Biomed Opt Express. 2013 Jul 17;4(8):1366-79. doi: 10.1364/BOE.4.001366. eCollection 2013.

Autoregressive model based algorithm for correcting motion and serially correlated errors in fNIRS.

Author information

Department of Radiology, University of Pittsburgh, 4200 Fifth Avenue, Pittburgh, PA 15260, USA ; Department of Bioengineering, University of Pittsburgh, 4200 Fifth Avenue, Pittburgh, PA 15260, USA.


Systemic physiology and motion-induced artifacts represent two major sources of confounding noise in functional near infrared spectroscopy (fNIRS) imaging that can reduce the performance of analyses and inflate false positive rates (i.e., type I errors) of detecting evoked hemodynamic responses. In this work, we demonstrated a general algorithm for solving the general linear model (GLM) for both deconvolution (finite impulse response) and canonical regression models based on designing optimal pre-whitening filters using autoregressive models and employing iteratively reweighted least squares. We evaluated the performance of the new method by performing receiver operating characteristic (ROC) analyses using synthetic data, in which serial correlations, motion artifacts, and evoked responses were controlled via simulations, as well as using experimental data from children (3-5 years old) as a source baseline physiological noise and motion artifacts. The new method outperformed ordinary least squares (OLS) with no motion correction, wavelet based motion correction, or spline interpolation based motion correction in the presence of physiological and motion related noise. In the experimental data, false positive rates were as high as 37% when the estimated p-value was 0.05 for the OLS methods. The false positive rate was reduced to 5-9% with the proposed method. Overall, the method improves control of type I errors and increases performance when motion artifacts are present.


(100.2960) Image analysis; (170.2655) Functional monitoring and imaging; (170.5380) Physiology; (300.0300) Spectroscopy

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center