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Caspian J Intern Med. 2013 Spring;4(2):627-35.

Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation.

Author information

1
Department of Social Medicine and Health, Babol University of Medical Sciences, Babol, Iran.

Abstract

This review provides the basic principle and rational for ROC analysis of rating and continuous diagnostic test results versus a gold standard. Derived indexes of accuracy, in particular area under the curve (AUC) has a meaningful interpretation for disease classification from healthy subjects. The methods of estimate of AUC and its testing in single diagnostic test and also comparative studies, the advantage of ROC curve to determine the optimal cut off values and the issues of bias and confounding have been discussed.

KEYWORDS:

Area under the curve (AUC); Bias; Nonparametric; Parametric; ROC curve; Sensitivity; Specificity

PMID:
24009950
PMCID:
PMC3755824

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