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Science. 2013 Sep 6;341(6150):1113-6. doi: 10.1126/science.1241210.

Neuroendocrine control of Drosophila larval light preference.

Author information

1
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors--the Bolwig's organ and the peripheral class IV dendritic arborization neurons--to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.

PMID:
24009394
PMCID:
PMC3906047
DOI:
10.1126/science.1241210
[Indexed for MEDLINE]
Free PMC Article
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