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Clin Cancer Res. 2013 Sep 15;19(18):4905-7. doi: 10.1158/1078-0432.CCR-13-1694. Epub 2013 Sep 5.

Can stroma reaction predict cancer lethality?

Author information

1
Authors' Affiliations: Departments of Medicine, Surgery, Biomedical Sciences, and Biostatistics and Bioinformatics Center, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, California.

Abstract

Stromal features in carcinomas may provide a relatively consistent means to stratify patients afflicted with solid tumors. Stroma-derived transcriptome signatures can now be used to make predictions about patient survival, suggesting the potential for their clinical application in precision medicine to predict disease progression and emergence of therapeutic resistance.

PMID:
24009149
PMCID:
PMC3983789
DOI:
10.1158/1078-0432.CCR-13-1694
[Indexed for MEDLINE]
Free PMC Article
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