Format

Send to

Choose Destination
Diabetes Res Clin Pract. 2013 Oct;102(1):e1-4. doi: 10.1016/j.diabres.2013.08.005. Epub 2013 Aug 19.

Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo.

Author information

1
Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, 2-1-7 Fukushima-ku, Osaka 553-0003, Japan; Division of Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, 2-1-7 Fukushima-ku, Osaka 553-0003, Japan. Electronic address: ydaisuke-kyoto@umin.ac.jp.

Abstract

We examined GLP-1 secretion from the pancreas of a patient with glucagonoma and pancreatic resection by measuring GLP-1 after meal ingestion or selective arterial calcium injection, and immunohistochemical analysis. Our findings support the notion that GLP-1 is secreted from pancreatic α cells in humans.

KEYWORDS:

GIP; GLP-1; Glucagon-like peptide-1; Glucagonoma; MEN1; Pancreatic α cells; glucagon-like peptide 1; glucose-dependent insulinotropic polypepide; multiple endocrine neoplasia syndrome, type 1

PMID:
24008099
DOI:
10.1016/j.diabres.2013.08.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center