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Methods Mol Biol. 2013;1012:255-64. doi: 10.1007/978-1-62703-429-6_18.

Cell-based methods for the identification of MYC-inhibitory small molecules.

Author information

1
Cleveland BioLabs, Inc., Buffalo, NY, USA.

Abstract

Oncoproteins encoded by dominant oncogenes have long been considered as targets for chemotherapeutic intervention. However, oncogenic transcription factors have often been dismissed as "undruggable." Members of Myc family of transcription factors have been identified as promising targets for cancer chemotherapy in multiple publications reporting the requirement of Myc proteins for maintenance of almost every type of tumor. Here, we describe cell-based approaches to identify c-Myc small molecule inhibitors by screening complex libraries of diverse small molecules based on Myc functionality and specificity.

PMID:
24006071
PMCID:
PMC4577296
DOI:
10.1007/978-1-62703-429-6_18
[Indexed for MEDLINE]
Free PMC Article

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