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Am J Alzheimers Dis Other Demen. 2013 Nov;28(7):702-9. doi: 10.1177/1533317513500839. Epub 2013 Sep 4.

Antioxidant and cholinesterase inhibitory activity of a new peptide from Ziziphus jujuba fruits.

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1Young Researchers and Elite Club, Yazd Branch, Islamic Azad University, Yazd, Islamic Republic of Iran.


Antioxidant agents and cholinesterase inhibitors are the foremost drugs for the treatment of Alzheimer's disease (AD). In this study, a new peptide from Ziziphus jujuba fruits was investigated for its inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes as well as antioxidant activity. This peptide was introduced as a new peptide and named Snakin-Z. The Snakin-Z displayed considerable cholinesterase inhibition against AChE and BChE. The half maximal inhibitory concentration (IC50) values of Snakin-Z against AChE and BChE are 0.58 ± 0.08 and 0.72 ± 0.085 mg/mL, respectively. This peptide has 80% enzyme inhibitory activity on AChE and BChE at 1.5 mg/mL. The Snakin-Z also had the high antioxidant activity (IC50 = 0.75 ± 0.09 mg/mL). Thus, it is suggested that Snakin-Z may be beneficial in the treatment of AD. However, more detailed researches are still required as in vivo testing its anticholinesterase and antioxidant activities.


Alzheimer’s disease; Ziziphus jujuba fruits; acetylcholinesterase; antioxidant; butyrylcholinesterase

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