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Vasc Endovascular Surg. 2013 Nov;47(8):620-4. doi: 10.1177/1538574413503562. Epub 2013 Sep 4.

Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis.

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1
1General Surgery Residency Program, University of Kentucky, Lexington, KY, USA.

Abstract

PURPOSE:

To determine whether a correlation exists between chronic cerebrospinal venous insufficiency (CCSVI) and multiple sclerosis (MS).

MATERIALS AND METHODS:

A meta-analysis of the current literature was performed to evaluate the frequency of CCSVI, diagnosed by echo color Doppler criteria, in patients with MS and in normal controls.

RESULTS:

In all, 19 studies were identified from January 2005 through February 2013; however, 3 studies were excluded due to duplicate data and 3 additional studies because 0 patients fulfilled CCSVI criteria in both MS and control groups. In order to improve homogeneity, 4 outlier studies were also removed from the analysis. Analysis of the remaining 9 studies demonstrated a significant correlation between CCSVI and MS (odds ratio 1.885, P < .0001) with no significant heterogeneity of the studies (I (2) = 18, P = .279).

CONCLUSIONS:

The meta-analysis demonstrated a correlation between CCSVI and MS. However, there was no evidence that CCSVI has a causative role in MS.

KEYWORDS:

central nervous system; chronic cerebrospinal venous insufficiency; color Doppler; multiple sclerosis

PMID:
24005191
DOI:
10.1177/1538574413503562
[Indexed for MEDLINE]
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