Abstract
cDNA clones for rat serum amyloid P component (SAP) were isolated, and the derived amino acid sequence for pre-SAP was determined from the complete nucleotide sequence. Rat SAP is encoded by approximately 1 kb of mRNA, and the mature SAP protein is predicted to be 208 amino acids long. An increase in hepatic mRNA levels for rat SAP was found after administration of lipopolysaccharide, and SAP mRNA levels in livers of unstimulated male rats were lower than in hepatic RNA from female rats.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cricetinae
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DNA / genetics
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DNA / isolation & purification
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Female
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Gene Expression Regulation
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Humans
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Lipopolysaccharides / pharmacology
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Liver / metabolism
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Male
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Mesocricetus
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Mice
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Molecular Sequence Data
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Nucleic Acid Hybridization
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RNA, Messenger / biosynthesis
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Rats
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Rats, Inbred Strains
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Sequence Homology, Nucleic Acid
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Serum Amyloid P-Component / genetics*
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Sex Characteristics
Substances
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Lipopolysaccharides
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RNA, Messenger
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Serum Amyloid P-Component
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DNA