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Br J Cancer. 2013 Oct 1;109(7):1895-8. doi: 10.1038/bjc.2013.507. Epub 2013 Sep 3.

Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia.

Author information

1
1] Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, MMC715, 420 Delaware Street S.E., Minneapolis, MN 55455, USA [2] Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

BACKGROUND:

A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men.

METHODS:

In this population-based case-control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype.

RESULTS:

We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32-0.96). Hormone replacement therapy and reproductive factors were not associated with risk.

CONCLUSION:

Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.

PMID:
24002589
PMCID:
PMC3790163
DOI:
10.1038/bjc.2013.507
[Indexed for MEDLINE]
Free PMC Article
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