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Ann Ital Chir. 2013 Sep 3;84(ePub). pii: S2239253X13021282.

Breast myofibroblastoma in a young woman: a case report.


in English, Italian

Myofibroblastoma (MFB) is an uncommon benign mesenchymal tumor that may arise in several organs and tissue. Although most of reported cases were located in the breast, it is extremely rare, representing less than 1% of breast tumor. MFB has predominantly seen in elderly men, but some cases have been described in menopausal women. This lesion is a stromal tumor which has many morphologic variants including cellular, collagenized, epithelioid, palisaded, lipomatous, hemangiopericytoma-like, and infiltrant features. Even if its incidence has recently increased due to the mammary screening, only few cases have been reported in Literature and even less in young women. Physical examination discloses a solitary, unilateral, painless, freely movable, usual firm in consistency, non-tender nodule. Imaging investigations usually are not specific to establish the right diagnosis. Furthermore, findings from Fine-Needle Aspiration (FNA) may be confusing and nonspecific, making diagnosis of MFB possible only after surgical operation. Not evidence of malignant transformation, recurrence or distant metastasis after a follow-up period of 15 years have been reported in Literature when resection margins are free. Hereby the authors describe a rare case of breast MFB in a young woman.

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