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Cancer Lett. 2014 Jan 1;342(1):121-9. doi: 10.1016/j.canlet.2013.08.037. Epub 2013 Aug 31.

MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer.

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1
Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, PR China.

Abstract

The expression of miR-203 has been reported to be significantly down-regulated in esophageal cancer. We showed here that overexpression of miR-203 in esophageal cancer cells dramatically increased cell apoptosis and inhibited cell proliferation, migration and invasion as well as tumor growth and down-regulated miR-21 expression. We subsequently identified that small GTPase Ran was a target gene of miR-203. Furthermore, Ran restoration partially counteracted the tumor suppressive effects of miR-203 and increased miR-21 expression. Taken together, our findings suggest that miR-203 may act as novel tumor suppressor in esophageal cancer through down-regulating the expression of Ran and miR-21.

KEYWORDS:

Esophageal cancer; MiR-203; MiR-21; Ran; Tumor suppressor

PMID:
24001611
DOI:
10.1016/j.canlet.2013.08.037
[Indexed for MEDLINE]
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