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Crit Rev Biochem Mol Biol. 2013 Sep-Oct;48(5):465-75. doi: 10.3109/10409238.2013.831395. Epub 2013 Sep 3.

Solving the mystery of human sleep schedules one mutation at a time.

Author information

1
Department of Neurology, University of California San Francisco , San Francisco, CA , USA and.

Abstract

Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human sleep lead to unique opportunities for probing these territories. In this review, we summarize causative circadian mutations found from familial genetic studies to date. We also describe how these mutations mechanistically affect circadian function and lead to altered sleep behaviors, including shifted or shortening of sleep patterns. In addition, we discuss how the investigation of mutations can not only expand our understanding of the molecular mechanisms regulating the circadian clock and sleep duration, but also bridge the pathways between clock/sleep and other human physiological conditions and ailments such as metabolic regulation and migraine headaches.

PMID:
24001255
PMCID:
PMC4089902
DOI:
10.3109/10409238.2013.831395
[Indexed for MEDLINE]
Free PMC Article

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