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Angew Chem Int Ed Engl. 2013 Oct 18;52(43):11410-4. doi: 10.1002/anie.201305094. Epub 2013 Sep 2.

Predicting the rotational tumbling of dynamic multidomain proteins and supramolecular complexes.

Author information

1
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Am Fassberg 11, 37077 Göttingen (Germany); Max-Planck-Institut für Biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen (Germany). nare@nmr.mpibpc.mpg.de.

Abstract

Time is of the essence: The rotational motion of biomolecules depends on intra- and intermolecular interactions and thus on distinct functional states. A new method, called HYCUD accurately predicts rotational correlation times in complex dynamic systems. It gives insights into the motional behavior of multidomain proteins in their free form and in supramolecular complexes.

KEYWORDS:

NMR spectroscopy; hydrodynamic coupling; protein disorder; proteins; rotational diffusion

PMID:
24000220
DOI:
10.1002/anie.201305094
[Indexed for MEDLINE]

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