Format

Send to

Choose Destination
Mol Neurobiol. 2014 Feb;49(1):590-600. doi: 10.1007/s12035-013-8544-1. Epub 2013 Sep 3.

Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics.

Author information

1
Department of Physiology and Biophysics, School of Medicine, Health Sciences Center, A-1201, University of Louisville, 500 South Preston Street, Louisville, KY, 40202, USA.

Abstract

Exosomes have emerged as prominent mediators of neurodegenerative diseases where they have been shown to carry disease particles such as beta amyloid and prions from their cells of origin to other cells. Their simple structure and ability to cross the blood-brain barrier allow great opportunity to design a "makeup" with drugs and genetic elements, such as siRNA or miRNA, and use them as delivery vehicles for neurotherapeutics. Their role in neuroprotection is evident by the fact that they are involved in the regeneration of peripheral nerves and repair of neuronal injuries. This review is focused on the role of exosomes in mediating neurodegeneration and neuroprotection.

PMID:
23999871
PMCID:
PMC3951279
DOI:
10.1007/s12035-013-8544-1
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center